High-throughput screening for Hsp90 ATPase inhibitors.
Basic Information
ID: ALA1148663
Journal: Bioorg Med Chem Lett
Title: High-throughput screening for Hsp90 ATPase inhibitors.
Authors: Avila C, Hadden MK, Ma Z, Kornilayev BA, Ye QZ, Blagg BS.
Abstract: Recently, we reported a useful assay for the determination of yeast Hsp90 ATPase activity. Using this assay, high-throughput screening of approximately 10,000 compounds was performed to determine the feasibility of this assay on large scale. Results from high-throughput screening indicated that the assay was reproducible (av Z-factor = 0.80) and identified 0.57% of the compounds as Hsp90 inhibitors that exhibited IC50s less than 20 microM. The structures of several of these inhibitory scaffolds are reported along with their IC50 values.
CiteXplore: 16530412
DOI: 10.1016/j.bmcl.2006.02.063
Patent ID: ┄