Document Report Card

ID: ALA1148825

Journal: J Med Chem

Title: Beta- and gamma-di- and tripeptides as potential substrates for the oligopeptide transporter hPepT1.

Authors: Hubatsch I, Arvidsson PI, Seebach D, Luthman K, Artursson P.

Abstract: The hPepT1-mediated transport properties of a series of 11 synthesized beta- and gamma-peptides have been studied in Caco-2 cells. The results show that several of the compounds interact with the peptide transporter, but only two beta-dipeptides act as substrates and are transported across the cell monolayers. These two are less-efficient substrates than alpha-peptides. Larger derivatives than beta-dipeptides do not act as hPepT1 substrates, but instead, they appear to be substrates for P-glycoprotein efflux.

CiteXplore: 17887660

DOI: 10.1021/jm070148u