Chemoenzymatic synthesis and in vitro studies on the hydrolysis of antimicrobial monoglycosyl diglycerides by pancreatic lipase.
Basic Information
ID: ALA1148851
Journal: Bioorg Med Chem Lett
Title: Chemoenzymatic synthesis and in vitro studies on the hydrolysis of antimicrobial monoglycosyl diglycerides by pancreatic lipase.
Authors: Cateni F, Bonivento P, Procida G, Zacchigna M, Scialino G, Banfi E.
Abstract: Monoglucosyl and monogalactosyl diglycerides (MGDGs) with medium-long length acyl chains, identified as active components in Euphorbiaceae, were synthesized. They were examined for antimicrobial activity against Gram-positive, Gram-negative bacteria and fungi. MGDGs with two octanoyl groups at both 1- and 2-positions showed the most potent activity. The stereoselectivity of pancreatic lipase was investigated in vitro where the preference for the 1 position in MGDGs is strictly related to the length of the acyl chains.
CiteXplore: 17270436
DOI: 10.1016/j.bmcl.2007.01.019
Patent ID: ┄