Synthesis and SAR studies of potent imidazopyridine anticoccidial agents.

ID: ALA1148869

Journal: Bioorg Med Chem Lett

Title: Synthesis and SAR studies of potent imidazopyridine anticoccidial agents.

Authors: Liang GB, Qian X, Feng D, Fisher M, Brown CM, Gurnett A, Leavitt PS, Liberator PA, Misura AS, Tamas T, Schmatz DM, Wyvratt M, Biftu T.

Abstract: Diaryl imidazo[1,2-a]pyridine derivatives, such as 6a and 7i, have been synthesized and found to be potent inhibitors of parasite PKG activity. The most potent compounds are the 7-isopropylaminomethyl analog 6a and 2-isopropylamino analog 7i. These compounds are also fully active in in vivo assay as anticoccidial agents at 25 ppm in feed.

CiteXplore: 17475489

DOI: 10.1016/j.bmcl.2007.04.041

Patent ID: ┄