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ID: ALA1148889

Journal: Bioorg Med Chem Lett

Title: Biaryl cannabinoid mimetics--synthesis and structure-activity relationship.

Authors: Worm K, Zhou QJ, Stabley GJ, DeHaven RN, Dolle RE.

Abstract: Synthesis, in vitro biological evaluation, and structure-activity relationships of a biaryl cannabinoid mimetic 2 are reported. Variations in the substitution pattern yielded a number of agonists with low nanomolar affinity. Replacing the phenol group by a methyl morpholino acetate group led to compound 28, a 500-fold selective CB(2) receptor agonist.

CiteXplore: 17507224

DOI: 10.1016/j.bmcl.2007.04.059