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ID: ALA1148889
Journal: Bioorg Med Chem Lett
Title: Biaryl cannabinoid mimetics--synthesis and structure-activity relationship.
Authors: Worm K, Zhou QJ, Stabley GJ, DeHaven RN, Dolle RE.
Abstract: Synthesis, in vitro biological evaluation, and structure-activity relationships of a biaryl cannabinoid mimetic 2 are reported. Variations in the substitution pattern yielded a number of agonists with low nanomolar affinity. Replacing the phenol group by a methyl morpholino acetate group led to compound 28, a 500-fold selective CB(2) receptor agonist.
CiteXplore: 17507224