Document Report Card

ID: ALA1148952

Journal: J Nat Prod

Title: A new ene-triyne antibiotic from the fungus Baeospora myosura.

Authors: Parish CA, Huber J, Baxter J, González A, Collado J, Platas G, Diez MT, Vicente F, Dorso K, Abruzzo G, Wilson K.

Abstract: The isolation and structure elucidation of 1 from the Basidomycete fungus Baeospora myosura is described. This new ene-triyne antibiotic was most potent against Gram-positive bacteria, while it was less active against Gram-negative bacteria and a yeast. MICs against several strains of Staphylococcus aureus were as low as 0.001 microg/mL. Analogues of 1 that did not contain the ene-triyne moiety were inactive against all microorganisms tested. The isolation of this new natural product was complicated by the highly reactive nature of the conjugated terminal polyacetylene.

CiteXplore: 15568786

DOI: 10.1021/np0497853