Activity-guided fractionation of the leaves of Ormosia sumatrana using a proteasome inhibition assay.
Basic Information
ID: ALA1148953
Journal: J Nat Prod
Title: Activity-guided fractionation of the leaves of Ormosia sumatrana using a proteasome inhibition assay.
Authors: Su BN, Hwang BY, Chai H, Carcache-Blanco EJ, Kardono LB, Afriastini JJ, Riswan S, Wild R, Laing N, Farnsworth NR, Cordell GA, Swanson SM, Kinghorn AD.
Abstract: Activity-guided fractionation of a chloroform-soluble extract of the leaves of Ormosia sumatrana, using a proteasome inhibition assay, led to the isolation of a new A-type proanthocyanidin derivative, 3'-O-cinnamoylprocyanidin A-2 (1), and a new cerebroside, sumatranoside (2). The structures of these two isolates were determined as epicatechin-(2 beta-->O-->7',4 beta-->8')-epicatechin-3'-O-cinnamate (1) and 1-O-(beta-d-glucopyranosyl)-(2S,3S,4R)-2N-[(2'R)-2'-hydroxy-tetracosanoyl]-9Z-octadecene-1,3,4-triol (2), respectively, by spectroscopic and chemical methods. Sumatranoside (2) exhibited proteasome inhibitory activity with an IC(50) value of 30 microM.
CiteXplore: 15568789
DOI: 10.1021/np040134g
Patent ID: ┄