Document Report Card

ID: ALA1148979

Journal: J Nat Prod

Title: Thiobutacin, a novel antifungal and antioomycete antibiotic from Lechevalieria aerocolonigenes.

Authors: Lee JY, Moon SS, Yun BS, Yoo ID, Hwang BK.

Abstract: A novel butanoic acid, thiobutacin (1), 4-(2-aminophenyl)-4-oxo-2-methylthiobutanoic acid (C11H13NO3S), was isolated from the culture broth of a soil actinomycete, Lechevalieria aerocolonigenes strain VK-A9. The structure of thiobutacin (1) was elucidated on the basis of the extensive 2D NMR spectral data including 1H-1H COSY, HMBC, HMQC, ROESY, and NOESY. Thiobutacin (1) showed antioomycete and antifungal activity against phytopathogenic Phytophthora capsici and Botrytis cinerea and the yeast Saccharomyces cerevisiae.

CiteXplore: 15620255

DOI: 10.1021/np049786v