Document Report Card

ID: ALA1149037

Journal: J Nat Prod

Title: Vanicosides A and B, protein kinase C inhibitors from Polygonum pensylvanicum.

Authors: Zimmermann ML, Sneden AT.

Abstract: Two new protein kinase C inhibitory glycosides, vanicosides A [1] and B [2] were isolated from Polygonum pensylvanicum (Polygonaceae) by chromatographic techniques guided by bioassays for PKC inhibition. The structures of these glycosides were established primarily by analysis of 1H- and homonuclear correlated nmr and high-resolution fab mass spectra of 1 and 2 and the derived octaacetate, 3. Both glycosides were found to have p-coumaryl esters at the 1, 3, and 6 carbons of sucrose and a feruloyl ester at the 6' carbon. Vanicoside A [1] also had an acetate group at the 2' carbon.

CiteXplore: 8176400

DOI: 10.1021/np50104a007