Document Report Card

ID: ALA1149040

Journal: J Nat Prod

Title: Two new macrolide sesquiterpene pyridine alkaloids from Maytenus emarginata: emarginatine G and the cytotoxic emarginatine F.

Authors: Kuo YH, King ML, Chen CF, Chen HY, Chen CH, Chen K, Lee KH.

Abstract: Two new macrolide sesquiterpene pyridine alkaloids, emarginatine F [1] and emarginatine G [2], were isolated from Maytenus emarginata. The structural determinations of 1 and 2 by 2D nmr techniques and spectral comparison with a related compound, emarginatine A [3], are discussed. Biological evaluation showed that emarginatine F [1] demonstrated strong cytotoxicity against human epidermoid carcinoma of the nasopharynx (KB), ileocecal adenocarcinoma (HCT-8), melanoma (RPMI-7951) and medulloblastoma (TE-671) tumor cells, and against murine leukemia (P-388).

CiteXplore: 8176403

DOI: 10.1021/np50104a011