Document Report Card

ID: ALA1149067

Journal: J Nat Prod

Title: Ochrindoles A-D: new bis-indolyl benzenoids from the sclerotia of Aspergillus ochraceus NRRL 3519.

Authors: de Guzman FS, Bruss DR, Rippentrop JM, Gloer KB, Gloer JB, Wicklow DT, Dowd PF.

Abstract: Four new prenylated bis-indolyl benzenoid metabolites (ochrindoles A-D; 1-4) were isolated from antiinsectan organic extracts of the sclerotia of Aspergillus ochraceus (NRRL 3519). The structures of these compounds were determined primarily through HMBC, selective INEPT, and NOESY experiments. These compounds displayed moderate activity in feeding assays against the corn earworm Helicoverpa zea and the driedfruit beetle Carpophilus hemipterus. Compounds 1-4 also exhibited activity against Gram-positive bacteria.

CiteXplore: 8064296

DOI: 10.1021/np50107a011