Document Report Card

ID: ALA1149087

Journal: J Med Chem

Title: Anticancer and antimalarial efficacy and safety of artemisinin-derived trioxane dimers in rodents.

Authors: Posner GH, McRiner AJ, Paik IH, Sur S, Borstnik K, Xie S, Shapiro TA, Alagbala A, Foster B.

Abstract: In only four chemical steps from naturally occurring artemisinin (1), trioxane dimers 6 and 7 were prepared on a multigram scale in overall 32-44% yields. In mice, both isonicotinate N-oxide dimer 6 and isobutyric acid dimer 7 were considerably more antimalarially efficacious than clinically used sodium artesunate (2) via both oral and intravenous administration. In the transgenic adenocarcinoma of mouse prostate model, some of the trioxane dimers had potent anticancer activity.

CiteXplore: 14971910

DOI: 10.1021/jm0303711