Document Report Card

ID: ALA1149089

Journal: J Med Chem

Title: Evaluation of potent and selective small-molecule antagonists for the CXCR2 chemokine receptor.

Authors: Widdowson KL, Elliott JD, Veber DF, Nie H, Rutledge MC, McCleland BW, Xiang JN, Jurewicz AJ, Hertzberg RP, Foley JJ, Griswold DE, Martin L, Lee JM, White JR, Sarau HM.

Abstract: N,N'-Diarylureas were prepared, and the structure-activity relationship relative to the CXCR2 receptor was examined. This led to the identification of a potent and highly selective CXCR2 antagonist, which in addition was shown to be functionally active both in vitro against human neutrophils and in vivo in rabbit models of ear edema and neutropenia.

CiteXplore: 14998320

DOI: 10.1021/jm034248l