Document Report Card

Basic Information

ID: ALA1149197

Journal: Bioorg Med Chem Lett

Title: Design and synthesis of beta-amino-alpha-hydroxy amide derivatives as inhibitors of MetAP2 and HUVEC growth.

Authors: Sendzik M, Janc JW, Cabuslay R, Honigberg L, Mackman RL, Magill C, Squires N, Waldeck N.

Abstract: The rational design and synthesis of beta-amino-alpha-hydroxy amide derivatives as reversible inhibitors of methionine aminopeptidase-2 (MetAP2) with anti-proliferative activity against human umbilical vein endothelial cells (HUVECs) is described.

CiteXplore: 15149671

DOI: 10.1016/s0960-894x(04)00483-4