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ID: ALA1149217
Journal: Bioorg Med Chem Lett
Title: 3-trifluoromethyl-4-nitro-5-arylpyrazoles are novel K(ATP) channel agonists.
Authors: Peat AJ, Townsend C, Craig McKay M, Garrido D, Terry CM, Wilson JL, Thomson SA.
Abstract: This communication describes the discovery and synthesis of a series of 3-trifluoromethyl-4-nitro-5-arylpyrazoles as potent K(ATP) channel agonists. The most potent compound reported is ca. 100-fold more potent than diazoxide and exhibits selectivity for the SUR1 K(ATP) channel subtype. The 4-nitro substitutent on the pyrazole ring was required for activity, and limited SAR suggests that the de-protonated pyrazole maybe the active species.
CiteXplore: 14741296