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ID: ALA1149234
Journal: Bioorg Med Chem Lett
Title: Exploration of the P1 SAR of aldehyde cathepsin K inhibitors.
Authors: Catalano JG, Deaton DN, Furfine ES, Hassell AM, McFadyen RB, Miller AB, Miller LR, Shewchuk LM, Willard DH, Wright LL.
Abstract: The synthesis and biological activity of a series of aldehyde inhibitors of cathepsin K are reported. Exploration of the properties of the S(1) subsite with a series of alpha-amino aldehyde derivatives substituted at the P(1) position afforded compounds with cathepsin K IC(50)s between 52 microM and 15 nM.
CiteXplore: 14684342