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ID: ALA1149332
Journal: Bioorg Med Chem Lett
Title: Synthesis of benzoylpyrimidines as antagonists of the corticotropin-releasing factor-1 receptor.
Authors: Webb TR, Moran T, Huang CQ, McCarthy JR, Grigoriadis DE, Chen C.
Abstract: A series of benzoylpyrimidines derived from the anilinepyrimidine CRF(1) antagonists were synthesized. Several synthetic routes were developed to explore the SAR of this series of compounds. Compounds such as 8d (K(i) = 15 nM) exhibited high binding affinities at the human CRF(1) receptor.
CiteXplore: 15225687