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ID: ALA1149350
Journal: Bioorg Med Chem Lett
Title: Synthesis of novel chemical probes for the study of tanshinone binding proteins.
Authors: Lee JS, Han SY, Kim MS, Yu CM, Kim MH, Kim SH, Min YK, Kim BT.
Abstract: Novel diazirine or biotin-labeled tanshinone probes were synthesized and evaluated for TRAP inhibitory activity against RANKL-induced osteoclastogenesis in RAW264.7 cells. We found that diazirine-labeled derivatives (18 and 20) are potent inhibitors of RANKL-induced osteoclastogenesis. IC50 values were 18.02 and 15.00 microM, respectively. These probes will be useful reagents for investigating tanshinone-proteins interactions.
CiteXplore: 16872829