A strategy for the design of selective RNA binding agents. Preparation and RRE RNA binding affinities of a neomycin-peptide nucleic acid heteroconjuga...

ID: ALA1149371

Journal: Bioorg Med Chem Lett

Title: A strategy for the design of selective RNA binding agents. Preparation and RRE RNA binding affinities of a neomycin-peptide nucleic acid heteroconjugate library.

Authors: Hyun S, Lee KH, Yu J.

Abstract: We have successfully developed a new strategy for RNA ligand design, which applies the antisense concept to enhance and make more specific loop region interactions while at the same time preserving stem region anchoring. The heteroconjugates, prepared in this effort, have proven to be the most specific small molecule ligands against RRE RNA that have been uncovered to date.

CiteXplore: 16875816

DOI: 10.1016/j.bmcl.2006.06.094

Patent ID: ┄