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ID: ALA1149392
Journal: Bioorg Med Chem Lett
Title: PTP-1B inhibitors: cyclopenta[d][1,2]-oxazine derivatives.
Authors: Cho SY, Baek JY, Han SS, Kang SK, Ha JD, Ahn JH, Lee JD, Kim KR, Cheon HG, Rhee SD, Yang SD, Yon GH, Pak CS, Choi JK.
Abstract: A series of novel cyclopenta[d][1,2]-oxazine derivatives was prepared and evaluated for their inhibitory activity toward protein tyrosine phosphatase 1B (PTP-1B). Compound 6s was found to be an inhibitor of PTP-1B with nanomolar IC(50) value and high level of selectivity over other recombinant phosphatases.
CiteXplore: 16289879