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ID: ALA1149407
Journal: Bioorg Med Chem Lett
Title: Angelmarin, a novel anti-cancer agent able to eliminate the tolerance of cancer cells to nutrient starvation.
Authors: Awale S, Nakashima EM, Kalauni SK, Tezuka Y, Kurashima Y, Lu J, Esumi H, Kadota S.
Abstract: The CH(2)Cl(2)-soluble extract of Angelica pubescens was found to kill PANC-1 cancer cells preferentially under nutrition starvation at a concentration of 50 microg/ml, with virtually no cytotoxicity under nutrient-rich conditions. Further bioassay-guided fractionation and isolation led to the isolation of a novel compound named angelmarin as the primary compound responsible for the preferential cytotoxicity; the compound exhibited 100% preferential cytotoxicity against PANC-1 cells at a concentration of 0.01 microg/ml.
CiteXplore: 16288865