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ID: ALA1149469
Journal: Bioorg Med Chem Lett
Title: Hit-to-Lead studies: the discovery of potent, orally bioavailable thiazolopyrimidine CXCR2 receptor antagonists.
Authors: Baxter A, Cooper A, Kinchin E, Moakes K, Unitt J, Wallace A.
Abstract: A Hit-to-Lead optimisation programme was carried out on a high throughput screening hit, the thiazolopyrimidine 1, resulting in the discovery of the potent, orally bioavailable CXCR2 antagonist 29.
CiteXplore: 16297626