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ID: ALA1149471
Journal: Bioorg Med Chem Lett
Title: Pharmacophore-based virtual screening: the discovery of novel methionyl-tRNA synthetase inhibitors.
Authors: Kim SY, Lee YS, Kang T, Kim S, Lee J.
Abstract: We have performed virtual screening of a chemical database of 508,143 commercially available chemicals to search for new methionyl-tRNA synthetase (MetRS) inhibitors. In this study, potent lead compounds with a novel skeleton, including compound 27 with IC50 = 237 nM, were successfully identified as Escherichia coli MetRS inhibitors.
CiteXplore: 16824759