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ID: ALA1149477

Journal: Bioorg Med Chem Lett

Title: Monocyclic thiophenes as protein tyrosine phosphatase 1B inhibitors: capturing interactions with Asp48.

Authors: Wan ZK, Lee J, Xu W, Erbe DV, Joseph-McCarthy D, Follows BC, Zhang YL.

Abstract: A series of monocyclic thiophenes was designed and synthesized as PTP1B inhibitors. Guided by X-ray co-crystal structural information and computational modeling, rational design led to key interactions with Asp48 and improved inhibitory potency against PTP1B.

CiteXplore: 16806920

DOI: 10.1016/j.bmcl.2006.06.051