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ID: ALA1149503
Journal: Bioorg Med Chem Lett
Title: Growth inhibition of human cancer cells in vitro by T-type calcium channel blockers.
Authors: Lee JY, Park SJ, Park SJ, Lee MJ, Rhim H, Seo SH, Kim KS.
Abstract: This paper describes the preliminary biological results that novel T-type calcium channel blockers inhibit the growth of human cancer cells by blocking calcium influx into the cell, based on unknown mechanism on the cell cycle responsible for cellular proliferation. Among the selected compounds from compound library, compound 9c (KYS05041) was identified to be nearly equipotent with Cisplatin against some human cancers in the micromolar range.
CiteXplore: 16876410