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ID: ALA1149506
Journal: Bioorg Med Chem Lett
Title: Synthesis and in vitro biological evaluation of aryl boronic acids as potential inhibitors of factor XIa.
Authors: Lazarova TI, Jin L, Rynkiewicz M, Gorga JC, Bibbins F, Meyers HV, Babine R, Strickler J.
Abstract: A series of functionalized aryl boronic acids were synthesized and evaluated as potential inhibitors of factor XIa. Crystal structures of the protein-inhibitor complexes led to the design and synthesis of second generation compounds showing single digit micromolar inhibition against FXIa and selectivity against thrombin, trypsin, and FXa.
CiteXplore: 16876411