Synthesis of 3H-spiro[benzofuran-2,1'-cyclohexane] derivatives from naturally occurring filifolinol and their classical complement pathway inhibitory ...

ID: ALA1149522

Journal: Bioorg Med Chem Lett

Title: Synthesis of 3H-spiro[benzofuran-2,1'-cyclohexane] derivatives from naturally occurring filifolinol and their classical complement pathway inhibitory activity.

Authors: Useglio M, Castellano PM, Operto MA, Torres R, Kaufman TS.

Abstract: Six 3H-spiro[benzofuran-2,1'-cyclohexane] derivatives were synthesized from naturally occurring filifolinol, and their classical complement pathway inhibitory activity was determined. IC(50) values of the most potent compounds were comparable to the activity of the natural complement inhibitor K76-COOH and some synthetic tricyclic analogs of it.

CiteXplore: 16875818

DOI: 10.1016/j.bmcl.2006.07.029

Patent ID: ┄