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ID: ALA1149534
Journal: Bioorg Med Chem Lett
Title: 3-Arylamino-2H-1,2,4-benzothiadiazin-5-ol 1,1-dioxides as novel and selective CXCR2 antagonists.
Authors: Wang Y, Busch-Petersen J, Wang F, Ma L, Fu W, Kerns JK, Jin J, Palovich MR, Shen JK, Burman M, Foley JJ, Schmidt DB, Hunsberger GE, Sarau HM, Widdowson KL.
Abstract: A series of 3-arylamino-2H-1,2,4-benzothiadiazin-5-ol 1,1-dioxides were prepared and shown to be novel and selective antagonists of the CXCR2 receptor. Synthesis, structure and activity relationships, selectivity, and some developability properties are described.
CiteXplore: 17524641