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ID: ALA1149640
Journal: Bioorg Med Chem Lett
Title: Oxazolones as potent inhibitors of 11beta-hydroxysteroid dehydrogenase type 1.
Authors: Sutin L, Andersson S, Bergquist L, Castro VM, Danielsson E, James S, Henriksson M, Johansson L, Kaiser C, Flyrén K, Williams M.
Abstract: 2,5,5-Trisubstituted oxazolones were identified as potent inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1). The synthesis, structure-activity relationship and metabolic stability of these compounds are presented.
CiteXplore: 17600707