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ID: ALA1149658
Journal: Bioorg Med Chem Lett
Title: Pyridinylimidazole inhibitors of Tie2 kinase.
Authors: Semones M, Feng Y, Johnson N, Adams JL, Winkler J, Hansbury M.
Abstract: This communication details the evolution of the screening lead SB-203580, a known CSBP/p38 kinase inhibitor, into a potent and selective Tie2 tyrosine kinase inhibitor. The optimized compound 5 showed efficacy in an in vivo model of angiogenesis and a MOPC-315 plasmacytoma xenograft model.
CiteXplore: 17618114