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ID: ALA1149658

Journal: Bioorg Med Chem Lett

Title: Pyridinylimidazole inhibitors of Tie2 kinase.

Authors: Semones M, Feng Y, Johnson N, Adams JL, Winkler J, Hansbury M.

Abstract: This communication details the evolution of the screening lead SB-203580, a known CSBP/p38 kinase inhibitor, into a potent and selective Tie2 tyrosine kinase inhibitor. The optimized compound 5 showed efficacy in an in vivo model of angiogenesis and a MOPC-315 plasmacytoma xenograft model.

CiteXplore: 17618114

DOI: 10.1016/j.bmcl.2007.06.068