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ID: ALA1149802
Journal: Eur J Med Chem
Title: Chemiluminescent high-throughput microassay applied to imidazo[2,1-b]thiazole derivatives as potential acetylcholinesterase and butyrylcholinesterase inhibitors.
Authors: Andreani A, Burnelli S, Granaiola M, Guardigli M, Leoni A, Locatelli A, Morigi R, Rambaldi M, Rizzoli M, Varoli L, Roda A.
Abstract: The synthesis of a new series of imidazo[2,1-b]thiazole derivatives is described. They were tested as potential acetylcholinesterase and butyrylcholinesterase inhibitors by means of a chemiluminescent microassay. Although most of the new compounds did not show significant cholinesterase inhibition potency, three of them displayed selective antiacetylcholinesterase activity in the micromolar range.
CiteXplore: 17624631