Document Report Card

ID: ALA1150059

Journal: J Nat Prod

Title: Antifungal activity of meridine, a natural product from the marine sponge Corticium sp.

Authors: McCarthy PJ, Pitts TP, Gunawardana GP, Kelly-Borges M, Pomponi SA.

Abstract: Meridine [1], a polycyclic alkaloid derived from the marine sponge Corticium sp., was found to inhibit the growth of Candida albicans and Cryptococcus neoformans. Activity was also observed against Trichophyton mentagrophytes and Epidermophyton floccosum. Studies of the mechanism of action of this agent have shown an inhibition of nucleic acid biosynthesis.

CiteXplore: 1479383

DOI: 10.1021/np50089a016