Document Report Card

ID: ALA1150060

Journal: J Nat Prod

Title: Potent inhibitors of histamine release, two novel triterpenoids from the Okinawan marine sponge Penares incrustans.

Authors: Shoji N, Umeyama A, Motoki S, Arihara S, Ishida T, Nomoto K, Kobayashi J, Takei M.

Abstract: Two novel triterpenoids with an unusual 14-carboxyl group, penasterone [1] and acetylpenasterol [2], were isolated from the Okinawan marine sponge Penares incrustans. The structures of 1 and 2 were established mainly on the basis of nmr spectroscopic data. The relative stereochemistry of 1 was confirmed by single-crystal X-ray diffraction analysis. Compounds 1 and 2 potently inhibited histamine release from rat peritoneal mast cells induced by anti-IgE in a dose-dependent manner.

CiteXplore: 1282538

DOI: 10.1021/np50089a021