A new cytotoxic calyculinamide derivative, geometricin A, from the Australian sponge Luffariella geometrica.
Basic Information
ID: ALA1150121
Journal: J Nat Prod
Title: A new cytotoxic calyculinamide derivative, geometricin A, from the Australian sponge Luffariella geometrica.
Authors: Kehraus S, König GM, Wright AD.
Abstract: Geometricin A (1), together with the known compounds (7E,12E,18S,20Z)-variabilin (2), clathryimine A (3), tryptophol (4), and L-tryptophan, has been isolated from the methanol extract of the Australian sponge Luffariella geometrica. The structure of the new compound geometricin A (1) was elucidated by employing spectroscopic techniques (NMR, MS, UV, and IR) and by comparison of its NMR data with those of the calyculins and calyculinamides. Geometricin A (1) was found to be moderately cytotoxic toward the tumor cell lines HM02 and HEPG2 with GI50's of 1.7 and 2.8 microg/mL, respectively, and to have antialgal activity (growth inhibition zone 5 mm at the 50 microg level).
CiteXplore: 12141875
DOI: 10.1021/np010544u
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