Four new neuroprotective iridoid glycosides from Scrophularia buergeriana roots.
Basic Information
ID: ALA1150139
Journal: J Nat Prod
Title: Four new neuroprotective iridoid glycosides from Scrophularia buergeriana roots.
Authors: Kim SR, Lee KY, Koo KA, Sung SH, Lee NG, Kim J, Kim YC.
Abstract: Four new iridoid glycosides were isolated from a 90% MeOH extract of Scrophularia buergeriana roots and characterized as 8-O-E-p-methoxycinnamoylharpagide (1), 8-O-Z-p-methoxycinnamoylharpagide (2), 6'-O-E-p-methoxycinnamoylharpagide (3), and 6'-O-Z-p-methoxycinnamoylharpagide (4), respectively. In addition, three known iridoids were identified as E-harpagoside (5), Z-harpagoside (6), and harpagide (7). Compounds 1-7 significantly attenuated glutamate-induced neurotoxicity when added to primary cultures of rat cortical cells at concentrations ranging from 100 nM to 10 microM. The results obtained indicate that the iridoid glycosides isolated from S. buergeriana have significant protective effects against glutamate-induced neurodegeneration in primary cultures of rat cortical neurons.
CiteXplore: 12444706
DOI: 10.1021/np0202172
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