Document Report Card

ID: ALA1150176

Journal: J Nat Prod

Title: Majorenolide and majorynolide: a new pair of cytotoxic and pesticidal alkene-alkyne delta-lactones from Persea major.

Authors: Ma WW, Anderson JE, Chang CJ, Smith DL, McLaughlin JL.

Abstract: From the EtOH extract of the bark of Persea major, two bioactive compounds, majorynolide [1] and majorenolide [2], were isolated by activity-directed fractionation using brine shrimp. Their structures have been elucidated on the basis of spectral data as a pair of new alkene-alkyne delta-lactones, each with an exocyclic alkylidene methine carbon. Both 1 and 2 are moderately cytotoxic, and 2 is selectively pesticidal.

CiteXplore: 2614421

DOI: 10.1021/np50066a011