Document Report Card

ID: ALA1150220

Journal: J Nat Prod

Title: Additional cytotoxic polyacetylenes from the marine sponge Petrosia species.

Authors: Lim YJ, Park HS, Im KS, Lee C, Hong J, Lee M, Kim Dk D, Jung JH.

Abstract: Ten new polyacetylenic alcohols (1-6, 8-11), along with a known compound, petrocortyne C (7), were isolated from the marine sponge Petrosia sp. The gross structures were established based on NMR and MS data, and the absolute configuration was determined by the modified Mosher's method. These compounds displayed considerable cytotoxicity against a small panel of human solid tumor cell lines. Compounds 1-11 were further evaluated for in vitro inhibitory activity on DNA replication.

CiteXplore: 11170665

DOI: 10.1021/np000252d