Document Report Card

ID: ALA1150242

Journal: J Nat Prod

Title: Subinhibitory concentrations of antibiotics induce phenazine production in a marine Streptomyces sp.

Authors: Mitova MI, Lang G, Wiese J, Imhoff JF.

Abstract: Subinhibitory concentrations of antibiotics were found to enhance and modulate the production of new phenazines, streptophenazines A-H, in a marine Streptomyces isolate. The streptophenazines differ in length and substitution of an alkyl chain. The pattern of metabolites formed depends on the antibiotic used. In the presence of tetracycline, streptophenazines F and G were induced and the production of streptophenazines A-D was increased. When using bacitracin, mainly streptophenazine H was produced. Streptophenazines C and H showed moderate activity against Bacillus subtilis, while streptophenazine C was also active against Staphylococcus lentus.

CiteXplore: 18396903

DOI: 10.1021/np800032a