Document Report Card

ID: ALA1150255

Journal: J Nat Prod

Title: Spongian diterpenes with thyrotropin releasing hormone receptor 2 binding affinity from Spongia sp.

Authors: Carroll AR, Lamb J, Moni R, Hooper JN, Quinn RJ.

Abstract: High-throughput screening of a plant and marine invertebrate extract library to find natural products with rat thyrotropin releasing hormorne (TRH) receptor 2 binding affinity led to the isolation of four new (1-4) and one known (5) spongian diterpene from the sponge Spongia sp. The structures were assigned from interpretation of 2D NMR and high-resolution ESIMS data. The absolute configurations of 1-4 were proposed on the basis of analysis of their CD spectra. Diterpenes 1-5 showed rat TRH receptor 2 binding affinity with IC(50) values of 23 microM, 70 microM, 400 microM, 600 microM, and 1 mM, respectively.

CiteXplore: 18407692

DOI: 10.1021/np070658r