Document Report Card

ID: ALA1150271

Journal: J Nat Prod

Title: Corymbones A and B, phloroglucinols with thyrotropin releasing hormone receptor 2 binding affinity from the flowers of Corymbia peltata.

Authors: Carroll AR, Urban S, Lamb J, Moni R, Guymer GP, Forster PI, Quinn RJ.

Abstract: High-throughput screeing of a plant and marine invertebrate extract library to find natural products with rat thytotropin releasing hormone receptor 2 binding affinity led to the isolation of two new active acylphloroglucinols, corymbones A and B (1 and 2) from flowers of the Queensland tree Corymbia peltata. Their structures were assigned from interpretation of 2D NMR and high-resolution ESIMS data. Compounds 1 and 2 showed rat TRH receptor 2 binding affinity with IC 50 values of 23 and 19 microM, respectively.

CiteXplore: 18412395

DOI: 10.1021/np0706567