Document Report Card

ID: ALA1150342

Journal: J Med Chem

Title: Novel 3-carboxamide-coumarins as potent and selective FXIIa inhibitors.

Authors: Robert S, Bertolla C, Masereel B, Dogné JM, Pochet L.

Abstract: Recently, FXIIa was highlighted as an original attractive target for the development of new anticoagulant drugs with low rates of therapy-related hemorrhages. In this work, we describe the development of a new series of 3-carboxamide-coumarins that are the first potent and selective nonpeptidic inhibitors of FXIIa.

CiteXplore: 18459730

DOI: 10.1021/jm8002697