Isolation and structures of haterumadioxins A and B, cytotoxic endoperoxides from the Okinawan sponge Plakortis lita.

ID: ALA1150572

Journal: J Nat Prod

Title: Isolation and structures of haterumadioxins A and B, cytotoxic endoperoxides from the Okinawan sponge Plakortis lita.

Authors: Takada N, Watanabe M, Yamada A, Suenaga K, Yamada K, Ueda K, Uemura D.

Abstract: Cytotoxic endoperoxides, haterumadioxins A (1) and B (2), were isolated from the Okinawan sponge Plakortis lita. Their structures were determined by spectroscopic analysis. The absolute stereostructure of 1 was determined by degradation reactions and the modified Mosher's method. Haterumadioxins showed significant cytotoxicity against 38 human cancer cell lines.

CiteXplore: 11277756

DOI: 10.1021/np0003490

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