Document Report Card

ID: ALA1151149

Journal: J Nat Prod

Title: Antineoplastic agents, 107. Isolation of acteoside and isoacteoside from Castilleja linariaefolia.

Authors: Pettit GR, Numata A, Takemura T, Ode RH, Narula AS, Schmidt JM, Cragg GM, Pase CP.

Abstract: The southwestern Indian paintbrush, Castilleja linariaefolia, yielded extracts that displayed in vivo activity against murine P-388 (PS) lymphocytic leukemia. Separation guided by PS cell line inhibition led to isolation of cytotoxic compounds that were identified as the known glycosides acteoside [1] (ED50 2.6 micrograms/ml) and isoacteoside [2] (ED50 10 micrograms/ml). The identifications were established by spectral measurements and degradation studies. Mannitol was also found in this plant.

CiteXplore: 2380718

DOI: 10.1021/np50068a026