New cytotoxic terpenoids from the wood of Vepris punctata from the Madagascar Rainforest.
Basic Information
ID: ALA1151217
Journal: J Nat Prod
Title: New cytotoxic terpenoids from the wood of Vepris punctata from the Madagascar Rainforest.
Authors: Chaturvedula VS, Schilling JK, Miller JS, Andriantsiferana R, Rasamison VE, Kingston DG.
Abstract: Continuation of the chemical examination of the cytotoxic constituents of the wood of Vepris punctata resulted in the isolation of the two new terpenoids 1 and 2 and eight known compounds, glechomanolide (3), isogermafurenolide, (E,E)-germacra-1(10),4,7(11)-triene, alpha-amyrin, lupeol, lupeyl acetate, taraxerol, and 3-epi-taraxerol, in addition to the alkaloids reported reported previously. The structures of the two new compounds were established on the basis of 1D and 2D NMR spectroscopic data interpretation and chemical modifications. All the isolated compounds were tested against the A2780 human ovarian cancer cell line; the four sequiterpenoids showed moderate cytotoxic activity, while the six triterpenoids were inactive.
CiteXplore: 15165160
DOI: 10.1021/np0303512
Patent ID: ┄