Document Report Card

ID: ALA1151255

Journal: J Nat Prod

Title: Cyclic peptides from a Ruegeria strain of bacteria associated with the sponge Suberites domuncula.

Authors: Mitova M, Popov S, De Rosa S.

Abstract: Two new cyclic peptides, cyclo-(glycyl-L-seryl-L-prolyl-L-glutamyl) and cyclo-(glycyl-L-prolyl-L-glutamyl), have been isolated from the cell extract of a Ruegeria strain associated with cell cultures of Suberites domuncula. Three other cyclopeptides have been isolated for the first time from a natural source. Additionally, a new diastereoisomer of a known compound is reported. The structures of isolated compounds have been elucidated by means of spectroscopic data (1D-, 2D-NMR, HRESIMS) and chiral HPLC analysis. The new cyclopeptides exhibited moderate antimicrobial activity against Bacillus subtilis.

CiteXplore: 15270577

DOI: 10.1021/np049900+