Document Report Card

ID: ALA1151257

Journal: J Nat Prod

Title: Cytotoxic furanosesterterpenes from a marine sponge Psammocinia sp.

Authors: Choi K, Hong J, Lee CO, Kim DK, Sim CJ, Im KS, Jung JH.

Abstract: Three new (1-3) and seven known (4-10) cytotoxic furanosesterterpenes were isolated from a marine sponge Psammocinia sp. by bioactivity-guided fractionation. The structures were established on the basis of NMR and MS analyses. The geometry and absolute configuration were determined on the basis of optical rotation, NMR, and CD data. These compounds were evaluated for cytotoxicity against a small panel of five human tumor cell lines, and most of the compounds showed toxicity to SK-MEL-2. The mixture of compounds 7 and 8 displayed significant inhibition of DNA replication and moderate antioxidant profile.

CiteXplore: 15270579

DOI: 10.1021/np049922w