Document Report Card

ID: ALA1151283

Journal: J Nat Prod

Title: Bis(bibenzyls) from liverworts inhibit lipopolysaccharide-induced inducible NOS in RAW 264.7 cells: a study of structure-activity relationships and molecular mechanism.

Authors: Harinantenaina L, Quang DN, Takeshi N, Hashimoto T, Kohchi C, Soma G, Asakawa Y.

Abstract: The inhibition of lipopolysaccharide-induced NOS by 19 bis(bibenzyls) isolated from liverworts in RAW 264.7 macrophages was evaluated. The presence of phenolic hydroxyls and saturation at 7,8 and/or 7'/8' are required for inhibition of NO production. Among the compounds tested, marchantin A was the most potent, and its inhibitory activity was consistent with the inhibition of LPS-induced iNOS mRNA.

CiteXplore: 16378374

DOI: 10.1021/np0502589