Document Report Card

ID: ALA1151286

Journal: J Nat Prod

Title: Nostocarboline: isolation and synthesis of a new cholinesterase inhibitor from Nostoc 78-12A.

Authors: Becher PG, Beuchat J, Gademann K, Jüttner F.

Abstract: A new quaternary beta-carboline alkaloid, nostocarboline, was isolated from the freshwater cyanobacterium Nostoc 78-12A, and its constitution was assigned by 2D-NMR methods. The structure was proven by its total synthesis starting from norharmane via chlorination at C-6 and methylation at N-2. Nostocarboline was found to be a potent butyrylcholinesterase (BChE) inhibitor, with an IC(50) of 13.2 microM. The related 2-methylnorharmane, which is present in the human brain and might be relevant to Parkinson's disease (PD), was also determined to be a BChE inhibitor (11.2 microM). These inhibitory concentrations are comparable to galanthamine, an approved drug for the treatment of Alzheimer's disease (AD). Nostocarboline can thus be considered as a lead for the development of novel neurochemicals.

CiteXplore: 16378379

DOI: 10.1021/np050312l