Document Report Card

ID: ALA1151654

Journal: J Nat Prod

Title: Antineoplastic and piscicidal 1-alkyldaphnane orthoesters from Pimelea species.

Authors: Tyler MI, Howden ME.

Abstract: Five biologically active daphnane orthoesters have been isolated from Pimelea species (Thymelaeaceae). Four of these possessing antineoplastic activity against in vivo murine P-388 lymphocytic leukemia are gnidimacrin from P. ligustrina, simpleximacrin from P. simplex, linimacrin d and Pimelea factor P3 from P. linifolia. Linimacrin c from P. linifolia and the other four compounds showed piscicidal activity. Gnidimacrin and Pimelea factor P3 have previously been isolated from other members of the Thymelaeaceae. Simpleximacrin and linimacrins c and d are new compounds.

CiteXplore: 4031900

DOI: 10.1021/np50039a012