Document Report Card

ID: ALA1151720

Journal: J Nat Prod

Title: Citreamicins with potent gram-positive activity.

Authors: Hopp DC, Milanowski DJ, Rhea J, Jacobsen D, Rabenstein J, Smith C, Romari K, Clarke M, Francis L, Irigoyen M, Luche M, Carr GJ, Mocek U.

Abstract: Two new xanthone antibiotics, citreamicin delta (1) and epsilon (2), with potent activity against Gram-positive pathogens including multidrug-resistant Staphylococcus aureus (MDRSA) were discovered. Compounds 1 and 2 exhibited MIC values < 1 microg/mL versus a number of resistant strains. The compounds were obtained from EtOAc extracts of Streptomyces vinaceus and were purified by countercurrent chromatography and reversed-phase HPLC. Their structures were elucidated using primarily NMR and mass spectroscopy.

CiteXplore: 19053507

DOI: 10.1021/np800503z